基于多源信息融合的肿瘤热消融导航与热场测量方法
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1.福州大学机械工程及自动化学院福州350108; 2.福建省智慧医工联合工程研究中心福州350108; 3.福建省肿瘤医院福州350014

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TH89TP391.9

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福建省高校产学研合作项目(2023Y4019)、福建省卫健委重大科研专项项目(2022ZD01006)、福建省卫健委医学创新课题项目(2022CXA015)资助


Navigation and thermal field measurement method for tumor thermal ablation based on multi-source information fusion
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1.School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou 350108, China; 2.Fujian Engineering Research Center of Joint Intelligent Medical Engineering, Fuzhou University, Fuzhou 350108, China; 3.Fujian Cancer Hospital, Fuzhou 350014, China

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    摘要:

    针对肿瘤热消融过程中穿刺路径依赖经验判断、消融热场难以客观量化表征的问题,提出一种基于多源信息融合的肿瘤热消融导航与热场测量方法。在统一时空基准下,融合术前多物理场有限元仿真(FEA)、术中增强现实(AR)视觉定位与计算机断层扫描(CT)测温反演算法,实现穿刺路径的可视化精准引导以及消融温度场的三维定量重建。通过多物理场建模建立消融参数与组织热响应及损伤分布之间的映射关系,为术前布针规划提供能量覆盖约束;借助增强现实技术完成虚拟规划路径与物理手术空间的高精度配准,引导术中针道操作;结合计算机断层扫描值与温度之间的标定关系,对术中影像进行体素级温度反演,实现消融热场的实时量化表达。依托离体猪肝微波消融实验与腹部穿刺模体实验,对导航与热场测量框架开展系统验证。实验表明,在消融范围预测、穿刺路径引导及热场重建等关键环节均表现出良好的准确性与稳定性,整体误差水平满足肿瘤热消融的临床安全要求。相关工作实现了由几何路径引导向消融热场物理量化描述的转变,为热消融手术过程中的规划验证、疗效评估与决策优化提供了客观、可视的测量学依据。

    Abstract:

    To address the reliance on experience-based puncture guidance and the lack of objective quantification of thermal fields during tumor thermal ablation, a navigation and thermal-field measurement scheme based on multi-source information fusion is presented. Within a unified spatiotemporal reference framework, preoperative multiphysics finite element analysis (FEA), intraoperative augmented reality(AR)-based visual localization, and computed tomography(CT)-based thermometry are integrated to enable visualized puncture guidance and three-dimensional quantitative reconstruction of the ablation temperature field. Multiphysics modeling establishes the relationship between ablation parameters, tissue thermal response, and damage distribution, providing energy-coverage constraints for preoperative needle placement planning. Augmented reality technology supports accurate registration between virtual planning data and the physical surgical space, facilitating intraoperative needle guidance, while calibration between computed tomography values and temperature enables voxel-level temperature inversion from intraoperative imaging for objective thermal-field measurement. Ex vivo porcine liver ablation experiments and abdominal phantom puncture experiments are conducted to verify the navigation and thermal-field measurement framework. Experimental observations indicate that favorable accuracy and stability are achieved in ablation zone prediction, puncture path guidance, and thermal-field reconstruction, with overall performance satisfying clinical safety requirements for tumor thermal ablation. The presented scheme enables a transition from purely geometric navigation toward physically quantitative characterization of ablation thermal fields, providing objective metrological support for planning validation, intraoperative assessment, and decision optimization.

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刘天晟,何炳蔚,陈杰,王小珑,陈济鸿,方主亭.基于多源信息融合的肿瘤热消融导航与热场测量方法[J].仪器仪表学报,2026,47(3):233-244

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  • 在线发布日期: 2026-05-22
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