Magnetic labeling of biomolecules is a crucial technique in biomolecular analysis and manipulation. However, existing detection systems for magnetically labeled molecules often suffer from limited detection targets and restricted application scenarios. Magnetically labeled molecules can be driven by external magnetic fields, and their motions can be monitored using a thickness-shear quartz oscillator sensor. These molecular motions are influenced by both the intrinsic properties of the molecules and the characteristics of the carrier fluid. By analyzing the corresponding motion signals, the properties of the molecules or the carrier medium can be effectively characterized. In this work, a magneto-acoustic integrated multi-parameter detection system for magnetically labeled biomolecules is developed, providing enhanced flexibility for diverse detection applications. The system employs direct digital synthesis (DDS) signal generators as excitation sources for both the magnetic field and the sensor oscillation. Coordinated control between the DDS modules and computer software allows automatic tuning of excitation frequencies to achieve the optimal signal-to-noise ratio (SNR). The sensor output signals are demodulated to extract molecular motion components, which are then processed and analyzed to derive multiple signal features for multi-parameter molecular characterization. Experimental results demonstrate that the system successfully extracts modulated molecular motion signals from the sensor output, and the frequency optimization algorithm effectively enhances the SNR of the sensor signals. Consequently, the system enables quantitative detection of molecular concentration at the ng/mL level and hydrodynamic size at the nanometer scale. The developed instrument serves as an open and extensible platform for multi-parameter detection and biochemical process monitoring of magnetically labeled biomolecules, representing a novel and versatile technology for advanced biomolecular sensing.