With the constant improvement of the system frequency, many noise appeared, which can cause the deterioration of the system performance and make the signal integrity problems to become more and more serious. Crosstalk is a frequently encountered problem, which is caused by the capacitive coupling and the inductive coupling as the reason of edge filed generated between aggressive lines and victim lines. On the basis of the analysis of the causes of crosstalk, this paper introduced how to use a 2D field solver to solve per unit length inductance and the capacitance matrix so as to establish the SPICE circuit of transmission lines and analyze the signal integrity of multiple conductor transmission line system.