FPGA devices are more widely used in space remote sensing cameras. FPGA based on SRAM must be equipped with corresponding prom chips for storing FPGA programming data. The configuration is reloaded after power on.However, the configuration does not always succeed for it is easily affected by various factors. This paper describes FPGA configuration process, analyze the various factors affecting the configuration and make recommendations for design optimization. The Configuration circuits do not fail in hundreds of configuration tests after optimization..As space missions, FPGA configuration failure in remote sensing camera should never occur, in order to improve the reliability of poweron configuration, this paper presents a number of IO signal monitoring strategies. The use of high reliability antifuse FPGA which monitor the FPGA needed to be configured, can guarantee FPGA configuration almost 100% success. It has significant reference value in application of remote sensing cameras.