Aiming at the problem of water supply pipeline leakage signal detection and leakage point location, a leakage signal detection system for water supply pipeline is designed. The system is composed of two vibration signal acquisition terminals and upper computer software based on MATLAB. Based on the characteristics of leakage signal, the pre signal conversion circuit, band-pass filter circuit and ADC data acquisition circuit of vibration signal acquisition terminal are analyzed and designed. At the same time, the design principle and function of MCU program and upper computer software are analyzed and explained. VC-02 vibration calibrator and simulated water supply network are used to test the system functions of weak vibration signal acquisition and leakage point location. The test results show that the system can accurately collect the weak vibration signal with acceleration not less than 0.01g (1g = 9.80m / s ^ 2). The maximum relative error of locating the leakage point of 10m UPVC pipeline is 3.97%, and the average relative error is 3.51%.