Aiming at the problems of low precision and poor quality of analog signal acquisition in telemetry system, In this paper, a higher precision analog output card is designed under the trend of increasingly accurate, integrated and complex analog signal. In this design, FPGA centered logic controller and 16 bit high-precision DA converter are used to realize the high-precision DA conversion. The analog signal is switched out through the analog switch adg1606 with 16 bit channel, The output signal self check collects the analog signal in a round-loop switching mode at the switching rate of 175ns per channel through the analog switch, which ensures the high-quality acquisition of the output signal. After the design demonstration and test, the output voltage precision meets the design requirements ± 0.15%, the recovery voltage signal meets the design requirements ± 0.1%, which indicates that the output of analog signal is stable and reliable.