In the traditional multi-point distributed temperature measurement system, there are problems such as complex wiring, increased cost and real-time data processing requirements. Therefore, this paper designs a system that uses Bluetooth Mesh networking technology to achieve multi-point wireless temperature measurement. The system uses ARM as the core development board, PT100 as the temperature sensor head, uses 16-bit high-precision analog-to-digital converter ADS1110 to collect the temperature signal output by the PT100 temperature sensor, and realizes the wireless transmission of the temperature signal through the Bluetooth spiral antenna. Use the LabVIEW interface to display the temperature change curve in real time, while temperature alarm and temperature data can be saved. A method combining the least squares method and digital filtering is applied to the calibration of temperature data to eliminate the influence of system errors and interference signals and obtain high-precision temperature values. The experimental test results show that the temperature measurement system has the advantages of low cost, low power consumption, high precision, and convenient operation. At the same time, the temperature measurement accuracy can reach ±0.1℃, which can be widely used in the real-time acquisition and processing of temperature signals. It has certain practical value in it.