Interwire crosstalk is easy to occur due to numerous cables and long and narrow wiring space of EMU.By introducing the wiring situation under the vehicle and combining with the theory of crosstalk, a shielding protection scheme to reduce the crosstalk between cables is designed.In the CST cable studio, the cable simulation model was established under two different working conditions of M car and T car, and the crosstalk current and voltage in the sensor cable were obtained.Through simulation waveform comparison, the current and voltage after the installation of shielding are significantly reduced compared with the crosstalk before the installation of shielding, which conforms to the error range of the normal operation of the equipment, and verifies the effectiveness of the scheme.At the same time, it has certain engineering reference value to the layout and wiring of other types of electric locomotives.