In this paper,a multi-disciplinary and multi-domain collaborative design method of large-scale aperiodic phased array antenna is expounded,according to its characteristics. Then,the collaborative design about two antennas is carried out, focused on the typical process of collaborative design and several key control points. In the testing stage, the main indexes of the antenna are measured, the flatness of the radiating end face of antenna 1 is ≤1.2mm, the grating lobe level is ≤-20dB, the flatness of the radiating end face of antenna 2 is ≤1mm, and the grating lobe level is ≤-18dB. The measured data are in good agreement with the simulation results, and all the indexes are better than the design input requirements, which proves the effectiveness of the collaborative design method. Finally,the research direction in the future about large aperiodic array antenna is designated.