Aiming at the problem of powder being atomized unsatisfactory, delivered extensively, and adjusted inconveniently by present medical atomizer, an instrument of powder aerosol particles which consisted of sensors, nebulizer cup, PCI6251 acquisition card and LabVIEW was developed. Output signals of flow sensor and concentration sensor were collected by PCI6251 and processed by PC to adjust the flow and the powder mist concentration accurately and quickly, as well as to adjust the feed amount and feed rate by controlling the opening of flow valve and the rate of stepper motor. The performance experiment results prove that the instrument can quickly adjust and stabilize the value and powder mist concentration near the target value; the amount of powder can be adjusted as needed at any time and the adjustment time is less than16 s, when the value control error range is1%~1%, the concentration control error range is15%~15%.