Aiming at the problems of single factor and poor accuracy of meteorological observation in fishpond at present, a comprehensive meteorological observation system for fish ponds based on STM32 high performance processing chip is designed. By building functional modules such as data acquisition, data quality control and packet transfer, etc, the system can achieve real-time acquisition of meteorological observation data such as water temperature, humidity and radiation. At the same time, the message is transmitted to PC software for data monitoring and product processing. At the same time, by comparing and analyzing the operational data between the meteorological standard instrument and the system, solving the root mean square error of each element, the results are 0.2, 1, 0.3, 6 respectively, which complies with relevant meteorological business requirements, and the accuracy of the data collected by the system is preliminarily verified. The practical application results show that the comprehensive observation system has the advantages of stable and reliable operation, high measurement accuracy and high transmission efficiency, and can meet the needs of Agrometeorological services betterly.